Clinical

GERD Study

This research is being done to evaluate the acid exposure in the esophagus using esophageal 24 hour pH monitoring and esophageal manometry before and after a gastric sleeve, and compare it to that of a gastric bypass.

STUDY STATUS: Actively recruiting eligible patients.

Inclusion Criteria

Participants must meet ALL of the following inclusion criteria:

1. Fulfilled criteria for bariatric surgery as coined by National Institutes of Health conference.
2. Their age is ≥18 years and ≤70 years
3. The patient with symptoms of GERD needs to have diagnosis of GERD in their medical record and taking proton pump inhibitors on a daily basis.
4. The patient is able and willing to give written consent
5. The patient is willing to perform the pre-operative tests required for this study.
6. The patient is fit for both surgeries – LSG or LRYGB

Exclusion Criteria

Participants who meet any of the following criteria at the time of the baseline visit are NOT eligible to be enrolled in this study:

1. Previous bariatric surgery
2. Previous anti reflux procedure
3. Contra-indication to general anesthesia
4. Any medical condition, which in the judgment of the investigator and/or designee makes the subject a poor candidate for the investigational procedure
5. Pregnant or lactating female (women of child bearing potential must take a pregnancy test prior to surgery)
6. Hiatal hernia above 4cm (measured in the pre-operative gastroscopy).
7. Multiple surgeries in abdominal cavity or previous small bowel disease/resection
8. Patient on CPAP treatment for his/her OSA disease

IF ELIGIBLE: Discuss study with patient. If patient agrees, contact Aayush

POEM Study

Susan Haley  905-522-1155 x 32575

A study of an investigational surgical procedure for the treatment of achalasia and the inability of smooth muscle to move food down the esophagus.

STUDY STATUS:   No longer recruiting patients.

Inclusion Criteria

1. Subject is willing and able to provide an informed consent    
2. Subject is willing and able to comply with the study procedures
3. Subject speaks English and is able to understand the study procedures
4. A pregnancy test for women of childbearing potential prior to surgery     
5. Subject has a diagnosis of achalasia

Exclusion Criteria

1. Subject has previous mediastinal surgery; heller myotomy; esophageal endoscopic myotomy
2. Body mass index (BMI) > 40
3. Any anatomical esophageal anomaly that in the opinion of the investigator may render the intervention more difficult, such as sigmoid esophagus on the pre-operative barium swallow or hiatal hernia > 2cm.
4. Subject has any medical condition, which in the judgement of the investigator and/or designee makes the subject a poor candidate for the investigational procedure
5. Subject is a pregnant or lactating female
6. Subject is actively participating in another drug, biologic and/or device protocol

IF ELIGIBLE: Discuss study with patient. If patient agrees, contact Susan.